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ABSTRACT This study reveals the characteristics and relationship of sports injury and fatigue of the Winter Olympics athletes, and monitors the athletes' psychological condition through case analysis of excellent athletes, and provides empirical evidence for athletes' psychological training and preparation for the physical and mental health services of Winter Olympics. Through questionnaires, literature review and other methods to study the injury situation of Winter Olympics ice and snow athletes, the results show that the proportion of chronic lumbar and knee joint injuries, and repeated muscle strains of Chinese Winter Olympics ice and snow athletes is large, and the cure rate is not high. The preparation activities are neither paid enough attention or sufficient, and the rationality of training plan arrangement is insufficient. The main cause of injury is insufficient understanding of the mechanism of injury and illness among athletes and coaches. Individual elite athletes need to improve their coping skills and pay attention to their psychological fatigue. In view of the sports' psychological characteristics and the problems faced by winter athletes, personalized psychological intervention programs should be formulated.
RESUMO O presente estudo revela as características e a relação de lesões desportivas e fadiga de atletas participantes dos Jogos Olímpicos de Inverno, e monitora as condições psicológicas dos atletas através da análise de casos de atletas de alto desempenho, além de apresentar provas empíricas para o treino e a preparação psicológico dos atletas para os serviços de saúde física e mental dos Jogos de Inverno. Através de questionários, revisão de literatura e outros métodos de estudo das lesões que acometem os atletas dos Jogos Olímpicos de Inverno, em esportes que envolvem gelo e neve, os resultados mostram que é grande a proporção de lesões lombares crônicas, lesões articulares do joelho e recorrência de distensões musculares, e a taxa de cura não é alta. As atividades de preparação não são suficientemente consideradas e a racionalidade do plano de treinos é insuficiente. A principal causa de lesão é a falta de compreensão dos mecanismos que ocasionam lesões e enfermidades entre atletas e treinadores. Atletas individuais de elite precisam melhorar suas habilidades de enfrentamento e prestar atenção à sua fadiga psicológica. Tendo em conta as características psicológicas desportivas e os problemas existentes entre os atletas dos Jogos de Inverno, programas de intervenção psicológica personalizados devem ser formulados.
RESUMEN A través del análisis de casos de atletas de élite, este trabajo revela las características y la relación entre las lesiones deportivas y la fatiga de los atletas en los Juegos Olímpicos de invierno, monitorea el estado psicológico de los atletas y proporciona evidencia empírica para el entrenamiento psicológico de los atletas y la preparación del Servicio de salud física y mental En los Juegos Olímpicos de invierno.Juegos Olímpicos.Los resultados mostraron que la proporción de lesiones crónicas de la cintura y la rodilla y la tensión muscular repetida de los atletas de hielo y nieve en los Juegos Olímpicos de invierno en China era mayor.La tasa de curación no es alta.No se presta suficiente atención a las actividades preparatorias y a la racionalidad del plan de capacitación.La razón principal de la lesión es que los atletas y entrenadores no entienden el mecanismo de la lesión y la enfermedad.Los atletas individuales deben mejorar su capacidad de enfrentamiento y prestar atención a la fatiga psicológica.De acuerdo con las características psicológicas de los atletas de invierno y los problemas existentes, se formula un plan de Intervención Psicológica individualizado.
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Humans , Athletic Injuries/prevention & control , Snow Sports/injuries , Fatigue/prevention & control , AthletesABSTRACT
Chaperone-mediated autophagy (CMA) is a lysosome-dependent selective degradation pathway implicated in the pathogenesis of cancer and neurodegenerative diseases. However, the mechanisms that regulate CMA are not fully understood. Here, using unbiased drug screening approaches, we discover Metformin, a drug that is commonly the first medication prescribed for type 2 diabetes, can induce CMA. We delineate the mechanism of CMA induction by Metformin to be via activation of TAK1-IKKα/β signaling that leads to phosphorylation of Ser85 of the key mediator of CMA, Hsc70, and its activation. Notably, we find that amyloid-beta precursor protein (APP) is a CMA substrate and that it binds to Hsc70 in an IKKα/β-dependent manner. The inhibition of CMA-mediated degradation of APP enhances its cytotoxicity. Importantly, we find that in the APP/PS1 mouse model of Alzheimer's disease (AD), activation of CMA by Hsc70 overexpression or Metformin potently reduces the accumulated brain Aβ plaque levels and reverses the molecular and behavioral AD phenotypes. Our study elucidates a novel mechanism of CMA regulation via Metformin-TAK1-IKKα/β-Hsc70 signaling and suggests Metformin as a new activator of CMA for diseases, such as AD, where such therapeutic intervention could be beneficial.
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Objective:To observe the effect of modified Shaofu Zhuyutang combined with Zheng's Rebuzhen therapy on pain caused by adenomyosis (cold coagulation and blood stasis syndrome) and levels of vascular endothelial growth factor (VEGF), matrix metalloproteinases-9 (MMP-9), tissue inhibitors of matrix metalloproteinases (TIMP-1) and prostaglandin. Method:One hundred and twenty-eight patients were randomly divided into control group (63 cases) and observation group (65 cases) by random number table. Patients in control group got desogestrel and ethinylestradiol tablets since the first day of menstruation for consecutive 21 days, 1 granule/time, 1 time/day, and Zheng's Rebuzhen therapy for consecutive 10 days during the menstruation, 1 time/day. In addition to the therapy of control group, patients in observation group were also given Shaofu Zhuyutang, 1 dose/day. A course of treatment was 3 menstrual cycles. Before and after treatment, cox menstrual symptom scale (CMSS) of COX, visual simulation of dysmenorrheal (VAS), chronic pelvic pain, pictorial blood loss assessment chart (PBAC) and cold coagulation and blood stasis syndrome were scored. And uterine volume and endometrial thickness were evaluated by B-mode ultrasonography. And levels of VEGF, MMP-9, TIMP-1, prostaglandin E2 (PGE2), prostaglandin F2α(PGF2α) and cancer antigen were detected. Result:After treatment, the clinical efficacy in observation group was superior to that in control group (Z=2.445, PPP2α and CA125 were lower than those in control group (P2 were higher than those in control group (PConclusion:In addition to desogestrel and ethinylestradiol tablets combined with Zheng's Rebuzhen therapy, modified Shaofu Zhuyutang can relieve pain and hemorrhage and improve the clinical efficacy. The mechanism may be correlated with the regulation of expression levels of VEGF, MMP-9, TIMP-1 and prostaglandin.
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This paper took Qinghai Province as the research object, and constructed 20 secondary indicators of the two subsystems of Qinghai Tibetan medicine industry competitiveness and regional economic development. Drawing on the coupling coordination model, we empirically analyzed the coupling coordination degree between the Tibetan medicine industry competitiveness and regional economic development in Qinghai Province from 2008 to 2017. The results indicated that the development of Tibetan medicine industry in Qinghai lagged behind the development of regional economy, but the coupling coordination degree between the two showed an overall upward trend, which was divided into two stages. One was the maladjustment phase from 2008 to 2012, while the other was the coordination period from 2013 to 2017. Both the two subsystems were currently in primary coordination.
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Various posttranslational modifications (PTMs) participate in nearly all aspects of biological processes by regulating protein functions, and aberrant states of PTMs are frequently implicated in human diseases. Therefore, an integral resource of PTM-disease associations (PDAs) would be a great help for both academic research and clinical use. In this work, we reported PTMD, a well-curated database containing PTMs that are associated with human diseases. We manually collected 1950 known PDAs in 749 proteins for 23 types of PTMs and 275 types of diseases from the literature. Database analyses show that phosphorylation has the largest number of disease associations, whereas neurologic diseases have the largest number of PTM associations. We classified all known PDAs into six classes according to the PTM status in diseases and demonstrated that the upregulation and presence of PTM events account for a predominant proportion of disease-associated PTM events. By reconstructing a disease-gene network, we observed that breast cancers have the largest number of associated PTMs and AKT1 has the largest number of PTMs connected to diseases. Finally, the PTMD database was developed with detailed annotations and can be a useful resource for further analyzing the relations between PTMs and human diseases. PTMD is freely accessible at http://ptmd.biocuckoo.org.
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Humans , Databases, Protein , Disease , Genetics , Gene Regulatory Networks , Phosphorylation , Protein Processing, Post-Translational , Proteins , Metabolism , Search EngineABSTRACT
<p><b>OBJECTIVE</b>To study the clinical effect of segmental resection of the liver using Glissonean pedicle transection for primary liver cancer.</p><p><b>METHODS</b>The clinical data of 55 primary liver cancer patients admitted from January 2006 to October 2008 were analyzed retrospectively. Twenty-five of the patients underwent segmental resection of the liver by Glissonean pedicle transection (group A), and 30 underwent routine hepatectomy (group B). The positivity rate of the resection margin, micrometastasis in the hepatic parenchyma surrounding the lesions and postoperative recurrence rates were investigated.</p><p><b>RESULTS</b>The positivity rate of the resection margin was 4.0% in group A, significantly lower than that of group B. The number of histological micrometastasis was significantly higher in group A than in group B (16 vs 8). The median distance of histological micrometastasis was 6.8 mm (2.7-25.6 mm) in group A and 4.2 mm (2.4-9.0 mm) in group B. The one-year recurrence rate was significantly lower in group A than in group B (16% vs 26.7%).</p><p><b>CONCLUSION</b>Glissonean pedicle transection for segmental liver resection is a simpler procedure than routine hepatectomy for primary liver cancer and can reduce the number of histological micrometastasis and recurrence rate.</p>
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Female , Humans , Male , Carcinoma, Hepatocellular , Pathology , General Surgery , Hepatectomy , Methods , Liver Neoplasms , Pathology , General Surgery , Neoplasm Invasiveness , Neoplasm Recurrence, Local , Retrospective Studies , Survival Rate , Treatment OutcomeABSTRACT
OBJECTIVE@#To assess the effects of intracoronary diltiazem on no-reflow phenomenon of infarct-related artery (IRA) after emergent percutaneous transluminal coronary angioplasty or/and intracoronary stenting (PTCA/Stenting) in the patients with acute myocardial infarction (AMI).@*METHODS@#We studied 34 AMI patients with no-reflow phenomenon of IRA after emergent PTCA/Stenting between January 1999 and August 2005. Urokinase-treated group (n=16) was given intracoronary urokinase 30,0000 - 50,0000 units within 15 - 30 minutes between January 1999 and April 2002 while diltiazem-treated group (n=18) was given intracoronary diltiazem 0.5 - 2 mg within 10 - 30 minutes between May 2002 and August 2005. Fifteen minutes later, coronary arteriography (CAG) was performed and the thrombolysis in myocardial infarction (TIMI) flow grade was measured.@*RESULTS@#No apparent change of TIMI flow grade was found between pre-administration and post-administration of intracoronary urokinase, but TIMI flow grade was significantly improved after intracoronary diltiazem (P<0.01). TIMI flow grade of diltiazem-treated group was significantly higher than that of urokinase-treated group after the administration (P<0.05). The percentage of the patients who reached TIMI flow grade 3 after the intracoronary administration was higher in the diltiazem-treated group than that in the urokinase-treated group (P<0.01).@*CONCLUSION@#The intracoronary administration of diltiazem 0.5~2mg can effectively improve the no-reflow phenomenon after emergent PTCA/Stenting in patients with AMI.
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Angioplasty, Balloon, Coronary , Diltiazem , Therapeutic Uses , Myocardial Infarction , Therapeutics , No-Reflow Phenomenon , Drug Therapy , Stents , Treatment OutcomeABSTRACT
OBJECTIVE@#To analyze the risk factors for metastasis and recurrence of hepatocellular carcinoma (HCC) postoperatively.@*METHODS@#Data of 270 cases of postoperative HCC were analyzed by SPSS software retrospectively.@*RESULTS@#Out of the 270 cases, 162 got follow-up study and 136 showed metastasis and recurrence. Lots of risk factors induced the recurrence of HCC, such as AFP, tumor form, venous blood invasion, HBV infection, resection dimension and perioperative transfusion. There were different risk factors at different stages.@*CONCLUSION@#The early recurrence of HCC may be mediated by macro- or micro-vessel blood invasion and metastasis, the late recurrence by multicentric carcinogenesis or introhepatic cacinoma de novo.